FIG. 8.

Depletion of CD4⁺ T cells, but not depletion of CD8⁺ T cells, prior to infection in CCR2^−/− mice that received Ag-BMDC suppressed IL-4 production and decreased the fungal burden. (A) Log₁₀ IL-4 transcription in lungs compared to transcription in uninfected lungs 7 days postinfection (n = 6). (B and C) Fungal burden in lungs at 7 days (n = 6) and 14 days (n = 8) postinfection. (D) Survival after infection with 2 × 10⁶ yeast cells (n = 12, except for CCR2^−/− [n = 6]). (E and F) Transcription of IFN-γ and TNF-α in mice (n = 8 to 10). (G and H) Percentages and absolute numbers of CD8⁺ T cells 7 days postinfection (n = 6). *, P < 0.01 compared to CCR2^−/− mice. The data are the means and SEM of two experiments.