TABLE 1.
Geographical origins and derivations of the CSA-binding parasite lines
| Strain | Origin | Clonal linea | Referenceb | Comments |
|---|---|---|---|---|
| FCR3 | Ambiguous | Yes | 47 | Origin unknown due to historical contamination; perhaps from Southeast Asia; isogenic with several parasite lines, including ItG2, IT4, FVO, and A4 |
| CS2 | Ambiguous | Yes | 41 | Isogenic with FCR3; selected from ItG2 by CSA |
| 7G8 | South America | Yes | 3 | |
| HB3 | Honduras | Yes | 3 | Two var2csa gene copies, alleles A and B |
| NF54 | Ambiguous | No | 3 | Parent of 3D7 genome reference; isolated in Amsterdam |
| 3D7 | Ambiguous | Yes | This study | Parasite line that was cloned from NF54 |
| Pf2004 | West Africa | No | This study | Isolated from peripheral blood of a traveler who contracted malaria in West Africa |
| Pf2006 | West Africa | No | This study | Isolated from peripheral blood of a traveler who contracted malaria in West Africa |
a
Refers to whether the parasite line has been cloned to a single genotype.
b
Reference in which the CSA selection was first described.