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Time-to-death analysis from i.n. instillation studies. Except for the Δpgm mutant, infectious doses used were close to the calculated LD50 for that strain. The average doses (in parentheses) were calculated from two (Ybt+ and psn), three (irp2), and four (Δpgm) independent experiments. All studies were carried out to 14 days, with no further deaths after day 10. Data are averages from all LD50 studies, shown as percent survival on the indicated days postinfection.
