FIG. 1.

Anti-CSP antibody responses are species specific. Pooled sera from each group of 5 mice immunized with either P. berghei (Pb), P. berghei[PyCS], or P. yoelii (Py) Spz plus CQ were tested by ELISA to determine P. berghei (left) or P. yoelii (right) CSP-specific IgG reactivity, using long peptides spanning the N-terminal (PyNt or PbNt) or the C-terminal (PyCt or PbCt) domain of CSP, as well as peptides partially covering the central species-specific repeats (Repeats). The background reactivity of naive mouse serum was subtracted. The data are expressed as differences (Δ) of arbitrary units of fluorescence (AU). BPL, below positivity level. The data are representative of two or three independent experiments.