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. 2010 Mar 1;78(5):2182–2188. doi: 10.1128/IAI.01415-09

FIG. 5.

FIG. 5.

Liver stage quantification. Groups of 5 BALB/c mice were immunized with either P. berghei, P. berghei[PyCS], or P. yoelii Spz plus CQ. The control groups received injections of CQ alone (None). The results were expressed as mean liver parasite load log units ± standard error of the mean of n = 5 mice. The percent reduction of the liver parasite load was then calculated using the arithmetic values derived from the log liver load units. (Left) Liver parasite loads in immunized mice challenged with 60,000 P. berghei sporozoites. The percent reductions versus the control group were 100% in mice immunized with P. berghei and 99% in P. berghei[PyCS]-immunized mice. (Right) Liver parasite loads in immunized mice challenged with 40,000 P. yoelii sporozoites. The percent reductions versus the control group were 99% in mice immunized with P. yoelii, 48% in P. berghei-immunized mice, and 66% in mice immunized with P. berghei[PyCS] Spz plus CQ. *, P < 0.05 using one-way ANOVA followed by the Bonferroni posttest. BLD, below level of detection.