TABLE 1.
Serum cytokines/chemokines that remain unchanged in pregnant WT S. Typhimurium-infected mice relative to nonpregnant and pregnant S. Typhimurium ΔaroA-infected hosts
| Cytokine/chemokineb | Fold changea (mean ± SEM) in mice infected with: |
|||
|---|---|---|---|---|
| WT S. Typhimurium |
S. Typhimurium ΔaroA |
|||
| Nonpregnant | Pregnant | Nonpregnant | Pregnant | |
| C5a (complement component 5a) | 0.98 ± 0.57 | 1.13 ± 0.45 | 0.77 ± 0.48 | 1 ± 0.73 |
| GM-CSF | 1.16 ± 0.49 | 3.95 ± 0.98 | 2.59 ± 1.43 | 3.12 ± 1.28 |
| Eotaxin | 1.18 ± 0.48 | 4.2 ± 1.62 | 2.4 ± 1.31 | 3.55 ± 1.71 |
| sICAM-1 (CD54) | 1.02 ± 0.17 | 1.26 ± 0.24 | 0.78 ± 0.48 | 0.92 ± 0.62 |
| IFN-γ | 1.2 ± 0.6 | 1.58 ± 0.36 | 1.53 ± 0.92 | 1.56 ± 0.63 |
| IL-1α | 0.92 ± 0.41 | 2.35 ± 0.64 | 1.92 ± 1.34 | 2.05 ± 0.75 |
| IL-1β | 1.07 ± 0.41 | 2.29 ± 0.58 | 2.25 ± 1.67 | 1.97 ± 0.75 |
| IL-2 | 1.26 ± 0.59 | 2.25 ± 0.58 | 1.75 ± 0.72 | 1.70 ± 0.68 |
| IL-3 | 1.07 ± 0.49 | 1.40 ± 0.47 | 1.62 ± 0.89 | 1.10 ± 0.38 |
| IL-4 | 0.98 ± 0.31 | 1.53 ± 0.22 | 1.49 ± 0.67 | 1.56 ± 0.60 |
| IL-5 | 1.06 ± 0.67 | 3.98 ± 1.75 | 2.49 ± 1.43 | 3.07 ± 1.55 |
| IL-7 | 1.18 ± 0.37 | 2.26 ± 0.39 | 1.69 ± 0.79 | 2.20 ± 0.89 |
| IL-10c | 1.24 ± 0.58 | 6.33 ± 0.94 | 2.28 ± 1.20 | 4.34 ± 1.73 |
| IL-13 | 0.97 ± 0.37 | 1.46 ± 0.30 | 1.30 ± 0.66 | 1.69 ± 0.93 |
| IL12p70 | 0.95 ± 0.51 | 3.77 ± 2.51 | 2.46 ± 1.40 | 4.42 ± 2.48 |
| IL-16 | 1.01 ± 0.31 | 1.88 ± 0.36 | 1.68 ± 0.77 | 1.76 ± 0.57 |
| IL-17 | 1.06 ± 0.31 | 2.61 ± 1.08 | 1.85 ± 1.30 | 1.84 ± 0.82 |
| IL-23 | 1.04 ± 0.49 | 2.86 ± 0.78 | 2.22 ± 1.31 | 2.52 ± 1.18 |
| IL-27 | 1.45 ± 0.53 | 2.08 ± 1.07 | 1.80 ± 0.94 | 1.65 ± 0.79 |
| I-TAC (CXCL11) | 1.48 ± 0.69 | 2.59 ± 0.82 | 2.28 ± 1.34 | 2.31 ± 1.27 |
| M-CSF | 1.11 ± 0.48 | 1.34 ± 0.60 | 0.91 ± 0.55 | 0.89 ± 0.52 |
| MIP-1α (CCL3) | 1.10 ± 0.38 | 2.16 ± 0.36 | 2.18 ± 1.15 | 2.56 ± 0.99 |
| MIP-1β (CCL4) | 0.97 ± 0.46 | 4.36 ± 2.31 | 2.67 ± 1.92 | 3.63 ± 2.32 |
| RANTES (CCL5) | 1.44 ± 0.67 | 2.81 ± 0.68 | 2.97 ± 1.98 | 2.3 ± 0.75 |
| SDF-1 (CXCL12) | 0.65 ± 0.21 | 1.00 ± 0.44 | 0.57 ± 0.31 | 0.79 ± 0.42 |
| TARC (CCL17) | 1.10 ± 0.59 | 2.80 ± 0.82 | 2.40 ± 0.93 | 2.85 ± 1.30 |
| TIMP-1 | 1.60 ± 0.65 | 3.09 ± 0.56 | 1.94 ± 1.26 | 1.54 ± 0.98 |
| TNF-α | 1.22 ± 0.37 | 2.65 ± 0.51 | 1.97 ± 0.75 | 2.24 ± 0.45 |
| TREM-1 | 1.19 ± 0.51 | 3.1 ± 0.60 | 1.97 ± 0.89 | 2.03 ± 0.76 |
a
Data for each infected group are relative to the mean serum values for the respective noninfected nonpregnant or pregnant groups. There were 4 mice per group.
b
GM-CSF, granulocyte-macrophage colony-stimulating factor; M-CSF, macrophage colony-stimulating factor.
c
Values for IL-10 are significantly increased in the pregnant infected (WT S. Typhimurium and S. Typhimurium ΔaroA) animals relative to the nonpregnant infected group by Mann-Whitney U test.