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Alignments of substrate-binding pocket sequences of eukaryotic and prokaryotic kynureninase-like enzymes. The alignments show the locations of the kynureninase and hydroxykynureninase active-site signatures based on the structural and functional analysis of the human (hydroxy)kynureninase sequence (48). Accession numbers: NP_003928.1, kynureninase isoform A (Homo sapiens); YP_257899.1, Pseudomonas fluorescens Pf-5 kynureninase; NP_627839.1, S. coelicolor A3(2) hydrolase.
