FIG. 11.

Models for cytokinesis and intercellular bridge formation. (Left) Model of somatic cell abscission. CEP55 is essential in the recruitment of additional proteins (e.g., TSG101 and ALIX) that are required for abscission of the midbody (2, 3, 17). The regions of TSG101 and ALIX containing GPPX3Y motifs interact with the hinge region of CEP55 (14, 17) to complete cytokinesis. (Right) Model of the intercellular bridge in differentiating germ cells. The conserved GPPX3Y motif of TEX14 interacts strongly with the hinge region of CEP55 in differentiating germ cells to block CEP55 interactions with TSG101 and ALIX, resulting in formation of a stable intercellular bridge.