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OMTR was effective against drug-resistant HBV. Huh-7 cells were transfected with wild-type HBV or HBV strains resistant to lamivudine (LAM), adefovir (ADV), or entecavir (ETV). The cells were then treated with OMTR (0.4 mg/ml; 1.51 mM) for 24 h, followed by measurement of the HBV DNA replicative intermediates by the method described in Materials and Methods. The experiment was performed twice. Shown are means and SD. *, P < 0.01 versus untreated control.
