TABLE 1.
Susceptibility of E. coli strains to toxic compounds
| Strain | Genotype | MIC (μg/ml)a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OXA | CLOX | NAF | FAM | ATM | CAR | SBPC | CRMN | KAN | NOV | DOC | ||
| NKE96 | ΔacrB | 1 | 1 | 2 | 0.063 | 0.063 | 1 | 2 | 0.031 | 2 | 4 | 5,000 |
| NKE154 | ΔacrB-vector | 1 | 1 | 2 | 0.063 | 0.063 | 1 | 2 | 0.031 | 2 | 4 | 5,000 |
| NKE155 | ΔacrB-pnlpE | 8 | 16 | 16 | 0.25 | 0.25 | 8 | 16 | 0.25 | 8 | 16 | 40,000 |
| NKE127 | ΔacrB cpxAR | 0.5 | 1 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 1 | 4 | 2,500 |
| NKE158 | ΔacrB cpxAR-vector | 0.5 | 1 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 1 | 4 | 2,500 |
| NKE159 | ΔacrB cpxAR-pnlpE | 0.5 | 1 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 1 | 4 | 2,500 |
| NKE128 | ΔacrB tolC | 0.5 | 0.25 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 1 | 2 | 156 |
| NKE160 | ΔacrB tolC-vector | 0.5 | 0.25 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 1 | 2 | 156 |
| NKE161 | ΔacrB tolC-pnlpE | 0.5 | 0.25 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 2 | 2 | 156 |
| NKE126 | ΔacrB acrD | 0.5 | 1 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 2 | 4 | 5,000 |
| NKE156 | ΔacrB acrD-vector | 0.5 | 1 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 2 | 4 | 5,000 |
| NKE157 | ΔacrB acrD-pnlpE | 2 | 2 | 4 | 0.13 | 0.063 | 2 | 2 | 0.063 | 4 | 8 | 10,000 |
| NKE1365 | ΔacrB mdtABC | 1 | 1 | 1 | 0.063 | 0.063 | 1 | 2 | 0.031 | 2 | 4 | 5,000 |
| NKE1366 | ΔacrB mdtABC-vector | 1 | 1 | 1 | 0.063 | 0.063 | 1 | 2 | 0.031 | 2 | 4 | 5,000 |
| NKE1367 | ΔacrB mdtABC-pnlpE | 4 | 4 | 4 | 0.13 | 0.25 | 4 | 8 | 0.13 | 8 | 8 | 10,000 |
| NKE1316 | ΔacrB acrD mdtABC | 0.5 | 0.5 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 2 | 2 | 2,500 |
| NKE1368 | ΔacrB acrD mdtABC-vector | 0.5 | 0.5 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 2 | 2 | 2,500 |
| NKE1369 | ΔacrB acrD mdtABC-pnlpE | 0.5 | 0.5 | 1 | 0.063 | 0.063 | 1 | 1 | 0.031 | 4 | 2 | 2,500 |
a
MIC determinations were repeated at least three times. Values in boldface are larger than those of a corresponding parental strain harboring the pHSG398 vector. OXA, oxacillin; CLOX, cloxacillin; NAF, nafcillin; FAM, cefamandole; ATM, aztreonam; CAR, carbenicillin; SBPC, sulbenicillin; CRMN, carumonam; KAN, kanamycin; NOV, novobiocin; DOC, deoxycholate.