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. 2010 Feb 22;54(5):1981–1987. doi: 10.1128/AAC.01236-09

FIG. 2.

FIG. 2.

Susceptibility of wild-type, SFA-resistant, and SFA/NIM-resistant cells to SFA-1 and NIM811. Wild-type (DMSOr), SFA-1r, and SFA/NIMr clones were treated for 48 h with SFA-1 (A) or NIM811 (B). Viral RNA was quantified by qRT-PCR and normalized to total cellular RNA. The susceptibility curves of a representative experiment (A and B) show the level of viral RNA after drug treatment as the percentage of DMSO control cells. The standard deviations from six replicas are included. The experiment was repeated several times, and the same trend was observed. The EC50 for SFA-1 was 0.25, 4.55, and >10 μM in DMSOr, SFA-1r, and SFA/NIMr replicon-containing cells, respectively. The EC50 for NIM811 was 0.37, 1.26, and 4.26 μM in DMSOr, SFA-1r, and SFA/NIMr replicon-containing cells, respectively.