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Contribution of the NS5A mutations D320E and R356Q to resistance against NIM811. The mutations were introduced separately or together into the wild-type replicon (A), and the mutations were reversed in the CsA/NIMr clone (B). Susceptibility to NIM811 was analyzed, and the EC50s are shown in comparison to those of the wild-type and mutated NS5A gene containing all six mutations. The graphs are the results from two experiments, with standard deviations indicated by error bars.
