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Resistance to NIM811 is mediated by viral RNA
| Origin of total RNA | NIM811 EC50 (μM)a | BILN2061 EC50 (nM) |
|---|---|---|
| RNA transfected into cured CsA/NIMr cells | ||
| WT replicon | 0.12 | |
| DMSOr | 0.17 | |
| RNA transfected into Huh-cure cells | ||
| CsA/NIM811r | 1.5 (17.9) | 1.5 |
| DMSOr | 0.084 (1.0) | 1.4 |
Values in parentheses are the fold changes.
