TABLE 2.
Time-kill results for 40 MRSA strains exposed to telavancin
| Phenotype and telavancin concn | No. of strains with Δlog10 CFU/ml at: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 h |
6 h |
12 h |
24 h |
|||||||||
| −1a | −2a | −3a | −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | |
| All (n = 40) | ||||||||||||
| 4× MIC | 27 | 4 | 0 | 39 | 17 | 0 | 40 | 33 | 10 | 40 | 39 | 38 |
| 2× MIC | 23 | 3 | 0 | 37 | 4 | 0 | 40 | 32 | 8 | 40 | 39 | 36 |
| 1× MIC | 19 | 0 | 0 | 35 | 4 | 0 | 36 | 24 | 5 | 34 | 31 | 24 |
| VSSA (n = 27) | ||||||||||||
| 4× MIC | 16 | 0 | 0 | 26 | 13 | 0 | 27 | 26 | 9 | 27 | 27 | 26 |
| 2× MIC | 13 | 1 | 0 | 25 | 0 | 0 | 27 | 25 | 8 | 27 | 27 | 25 |
| 1× MIC | 10 | 0 | 0 | 24 | 3 | 0 | 27 | 20 | 5 | 23 | 21 | 16 |
| hVISA+VISA (n = 10) | ||||||||||||
| 4× MIC | 8 | 3 | 0 | 10 | 3 | 0 | 10 | 4 | 0 | 10 | 9 | 9 |
| 2× MIC | 7 | 2 | 0 | 9 | 3 | 0 | 10 | 4 | 0 | 10 | 9 | 8 |
| 1× MIC | 7 | 0 | 0 | 8 | 1 | 0 | 7 | 3 | 0 | 9 | 8 | 6 |
| VRSA (n = 3) | ||||||||||||
| 4× MIC | 3 | 1 | 0 | 3 | 1 | 0 | 3 | 3 | 1 | 3 | 3 | 3 |
| 2× MIC | 3 | 0 | 0 | 3 | 1 | 0 | 3 | 3 | 0 | 3 | 3 | 3 |
| 1× MIC | 2 | 0 | 0 | 3 | 0 | 0 | 2 | 1 | 0 | 2 | 2 | 2 |
a
−1, 90% killing; −2, 99% killing; −3, 99.9% killing.