TABLE 1.
Drug survival assays comparing strains F32-Tanzania and F32-ART
| Drug | Treatment duration (h)d | Drug dose (μM) | Time (days) to 5% parasitemiae |
|
|---|---|---|---|---|
| F32-Tanzania | F32-ART | |||
| ARTa | 48 | 9 | 16 ± 2f | 6 ± 1.5 |
| ART | 48 | 18 | 17g | 7 ± 1 |
| ART | 48 | 35 | NGh | 11 ± 2 |
| ART | 48* | 70 | NG | 17 |
| ART | 96* | 0.1 | NG | 15 |
| ART | 96* | 1 | NG | 16 |
| ATSb | 48 | 2.6 | 14 ± 0.5 | 6 ± 0 |
| ATS | 48* | 9 | 15 | 8 |
| CQc | 48 | 0.2 | 14 ± 0 | 14 ± 2 |
ART, artemisinin.
ATS, artesunate.
The dose tested corresponds to 10-fold the IC50 of chloroquine (CQ) for F32-Tanzania.
All experiments were carried out at least three times independently except those marked with an asterisk, which were carried out once.
Values express the time to reach 5% parasitemia in days ± standard deviations.
At day 21, two of three cultures recovered.
At day 21, only one of three cultures recovered.
NG, no growth at day 21.