FIG. 1.

Echinocandin inhibition profiles for product-entrapped 1,3-β-d-glucan synthase complexes obtained using a sigmoidal-response (variable-slope) curve. Echinocandin inhibition kinetics yielding 50% inhibitory concentrations (IC₅₀s) were obtained and are expressed in nanograms per milliliter. (A) Inhibition curves and 50% inhibitory concentrations (IC50) for micafungin (MCF) and for 1,3-β-d-glucan synthase complexes obtained from reference C. tropicalis ATCC 750 (750) and C. tropicalis CT-C1 strains. (B) Anidulafungin (ANF) titration curves for 1,3-β-d-glucan synthase complexes isolated from reference C. glabrata ATCC 90030, C. glabrata CG-C2, and C. glabrata CG-C3 strains.