TABLE 2.
RT amino acid substitutions in the RT connection domain derived from the RH/IN RTVs
| Patient sample | Genotype of connection domain of RT |
|---|---|
| 396a,b | D324D/E, Q334P, N348I, R356K, M357T, K358R, E370G, T377R, E399D, E404D |
| 471a,b | I326V, G335D, P345Q, F346Y, K347K/Q, N348N/I, R356K, M357M/R, K358K/R, G359S, K366R, A371A/V, T377Q, S379C, K390R, A400T, E404D |
| 440a,b | D324E, R356K, M357I/T, K358R, G359S, K366R, T369V, A371T, K390R, A400T |
| 62a | S322A, N348N/I, K358R, T369T/I, T377M, S379C, A400T, T403I, E404D/N |
| 477a,b | N348I, K358R, K390R, E396D, E399D, A400L |
| 384a,b | Y319H, G335D, R356K, M357K, K358R, G359S, K366R, T369V, A371V, I375V, A376V, T386A, K395K/R, A400T, T403M, W410Y |
| 429b | D324P, G333E, Q334L, R356K, M357I, K358R, A360A/T, K390R, A400T |
| 58b | V317V/A, I329L, R356K, K358R, A360V, E399D, A400T |
| 138b | Q334H, G335S, T338S, R356K, K358R, Q394L, E399D, A400T |
| 87b | I341F, N348I, M357T, K358R, T377M, K385R, P387P/S, T397T/I, A400T |
| 474b | G335D, P345Q, F346Y, N348I, R356K, M357T, K358R, T377R, S379C, T386I, K390R, A400I/L |
| 249b | V317V/A, D324E, I329L, Q334D, G335S, R356K, K358R, G359T, V365I, T369V, T377M, K390R, E396D, E399D, E404D |
| 439b | Q334Q/L, M357T, K358R, A360T, Q394T, E399D, A400T |
| 442b | V317A, G333E, Q334I/V, R356R/K, K358R, G359S, K366R, A371V, K388K/R, K390R, E399D, A400T |
a
Patient with reduced susceptibility to DLV, EFV, or NVP.
b
Patient with reduced susceptibility to ZDV.