FIG. 4.
RC fitness in the presence of treatment and extinction. In order to escape extinction during treatment, the fitness of the RC genotype needs to be above a certain threshold. This plot shows the maximal cost of resistance for a given eR and cR that permits long-term survival of the RC genotype. It was created by solving rwRC > d for cR, yielding cR < 1/(1 − eC,drug) − d/[r(1 − a + aeR)(1 − eC,drug)] as the condition for the bacteria to persist. The antimicrobial activity (a) has a value of 1.