TABLE 3.
Parameters for model describing bacterial growth
| Parameter | Description | Value (reference[s]) |
|---|---|---|
| r | Maximum growth rate of bacteria | 1.3/h (within host growth rate) (26, 59) |
| N0 | Bacterial population size when treatment is initiated | 105-109a |
| K | Carrying capacity of the population | 1010 |
| d | Kill rate | 0.5r, unless variedb |
| wij,A | Relative fitness of genotype ij, depending on whether antibiotic is administered (A = 1) or not (A = 0) | See Table 1 |
| μ→, μ← | Mutation rates at antibiotic resistance locus | 10−6 to 10−10/h, ∼2 × 10−6 to 10−10/division (53) |
| ν→, ν← | Mutation rates at compensatory locus | Unless stated otherwise, 10μ (63, 67) |
a
Symptom onset in bladder infection occurs at 102 CFU/ml (N0 ≈ 5 × 104) (80). Bacterial counts in bacteremia are 0.3 × 103 to 165 × 103 CFU/ml (N0 ≈ 1.5 × 106 to 8.25 × 108) (65).
b
Assuming bacteriostatic action and zero net growth, this corresponds to a reduction of bacterial load of 0.15/h (∼2 log within 24 h) for the default value of r = 1.3/h (27).