TABLE 3.
Binding affinities of ceftaroline, cefotaxime, and ceftriaxone for pneumococcal PBPs
| PBP | Strain (PEN susceptibility)a | GenBank accession no.b | IC50 (μg/ml) |
||
|---|---|---|---|---|---|
| Ceftaroline | Cefotaxime | Ceftriaxone | |||
| PBP1A | 1076 (S) | FJ439534 | 0.25 | 0.1 | 0.1 |
| 24 (R) | EU863721 | 0.125 | 0.125 | 0.25 | |
| 3413 (R) | FJ439539 | 0.25 | 0.25 | 0.25 | |
| 2527 (R) | FJ439536 | 0.25 | 0.25 | 0.25 | |
| PBP1B | 1076 (S) | NS | 0.25 | 0.25 | 0.1 |
| 24 (R) | NS | 0.1 | 8 | 1 | |
| 3413 (R) | NS | 0.25 | 4 | 4 | |
| 2527 (R) | NS | 0.25 | 0.25 | 0.125 | |
| PBP2X | 1076 (S) | FJ439542 | 0.1 | 0.25 | 0.1 |
| 24 (R) | EU863690 | 1 | 1 | 1 | |
| 3413 (R) | FJ439547 | 0.25 | 4 | 4 | |
| 2527 (R) | FJ439544 | 0.1 | 0.1 | 0.1 | |
| PBP2A | 1076 (S) | NS | 0.25 | 0.25 | 0.25 |
| 24 (R) | NS | 0.5 | 0.5 | 1 | |
| 3413 (R) | NS | 0.25 | 0.25 | 1 | |
| 2527 (R) | NS | 0.25 | 0.25 | 0.25 | |
| PBP2B | 1076 (S) | FJ439550 | 4 | >32 | >32 |
| 24 (R) | EU863659 | 0.5 | 16 | 16 | |
| 3413 (R) | FJ439555 | 2 | 16 | 16 | |
| 2527 (R) | FJ439552 | 4 | 4 | 4 | |
| PBP3 | 1076 (S) | FJ441591 | 0.1 | 0.1 | 0.1 |
| 24 (R) | FJ441590 | 0.1 | 0.1 | 0.25 | |
| 3413 (R) | FJ441599 | 0.1 | 0.1 | 0.25 | |
| 2527 (R) | FJ441595 | 0.25 | 0.1 | 0.25 | |