TABLE 3.
Selection of polymorphisms in new infections after therapy with DP
| Gene | SNP | Prevalence (%) in baseline samples (n = 111) | Selection (%) in new infections after prior DP therapy (%)a | Selection by DPb |
|---|---|---|---|---|
| pfcrt | K76T | 66.7 | 59.5 | No (0.43) |
| pfmdr1 | N86Y | 38.7 | 40.5 | No (0.85) |
| Y184F | 67.6 | 73.0 | No (0.54) | |
| D1246Y | 3.6 | 8.1 | No (0.50) |
a
Proportions of infections classified as mixed or mutant at each allele are shown.
b
“No” indicates that there was no selection observed; P values are shown in parentheses.