TABLE 3.
MIC measurement of antibiotic sensitization
| Organism and antibiotic | MIC μg/ml of: |
||
|---|---|---|---|
| Drug alone | Drug with 45 μMa of compound 1 | Drug with 75 μMa of compound 1 | |
| MRSA | |||
| Penicillin G | 32 | 4 | |
| Tetracycline | 16 | 16 | |
| Methicillin | 256 | 64 | |
| Ciprofloxacin | 4 | 2 | |
| Compound 1 | 64 | ||
| MDRAB | |||
| Imipenem | 16 | 2 | |
| Ciprofloxacin | 64 | 16 | |
| MDRAB 3340, imipenem | 64 | 8 | |
| MDRAB AB0043, imipenem | 16 | 4 | |
| MDRAB UH8407, imipenem | 1 | 0.125 | |
a
Compound 1 at 32 μg/ml (83 μM) was determined to be nontoxic to planktonic MRSA and MDRAB via colony count analysis.