TABLE 3.
Final estimates of the pharmacokinetic parameters and the respective CVs obtained with the three-compartment model
| Model and parametera | Units | Estimates for all patients |
||
|---|---|---|---|---|
| Mean | % CV | 95% CI | ||
| Structural model | ||||
| CL | liters/h | 10.0 | 37.5 | 2.65-17.35 |
| V1 | liters | 12.4 | 10.6 | 9.83-14.9 |
| V2 | liters | 52.2 | 6.25 | 45.8-58.6 |
| V3 | liters | 6,250 | 22.9 | 3,447-9,052 |
| Q1 | liters/h | 137 | 6.32 | 120-154 |
| Q2 | liters/h | 21.1 | 9.95 | 17.0-25.2 |
| Variance model | ||||
| IIV in CL | 0.292 | 56.2 | −0.0294-0.613 | |
| IIV in V3 | 0.00185 | 156 | −0.00379-0.00749 | |
| IIV in error | 0.306 | 50.0 | 0.00612-0.606 | |
| Residual variability | 0.0424 | 42.5 | 0.00712-0.0777 | |
a
CL, clearance; V, volume of distribution; V1, volume of distribution of the central compartment; V2, volume of distribution of the first peripheral compartment; V3, volume of distribution of the second peripheral compartment; Q1, intercompartmental clearance from V1 to V2; Q2, intercompartmental clearance from V1 to V3; IIV, interindividual variability.