TABLE 4.

Results of Monte Carlo simulations obtained by using the population model developed and a dosing regimen of 900 mg every 8 h

% protein binding	fAUC0-24/MIC ratio for MIC (μg/ml) ofa:
	0.125		0.25		0.5		1
	Lower 95% CI	Avg	Lower 95% CI	Avg	Lower 95% CI	Avg	Lower 95% CI	Avg
65	102	223	50.3	116	24.6	55.8	11.8	27.9
75	73.1	159	35.8	79.4	17.3	39.7	7.94	19.8
85	44.2	95.4	21.6	47.7	10.2	23.9	4.44	11.9

^aThe values are fAUC_0-24/MIC ratios for the averages and the lower 95% CIs for four values of the MIC. The MIC for GBS is 0.5 mg/liter, as determined from the clinical breakpoint of EUCAST (8). The minimal value for efficacy (5) is 27.