TABLE 3.
Anthrax postexposure prophylaxis murine model survival dataa
Test article | Dose (mg/kg/day) | Schedule | % survival on day 27 |
---|---|---|---|
Control | q12h | 0 | |
Faro | 10 | q4h | 77.8 |
Faro | 20 | q4h | 80 |
Faro | 40 | q4h | 80 |
Faro | 80 | q4h | 100 |
Faro | 10 | q6h | 30 |
Faro | 20 | q6h | 60 |
Faro | 40 | q6h | 90 |
Faro | 80 | q6h | 90 |
Faro | 10 | q12h | 0 |
Faro | 20 | q12h | 10 |
Faro | 40 | q12h | 20 |
Faro | 80 | q12h | 22.2 |
Cipro | 60 | q12h | 90 |
Abbreviations: Faro, faropenem; Cipro, ciprofloxacin; q4h, every 4 h; q6h, every 6 h; q12h, every 12 h.