TABLE 2.
In vitro activities of JNJ-Q2 and comparators against Gram-negative clinical isolates
| Organism | No. of isolates | Compound | MIC (μg/ml) |
||
|---|---|---|---|---|---|
| Range | 50% | 90% | |||
| Haemophilus influenzae | 24 | JNJ-Q2 | 0.008-0.015 | 0.008 | 0.015 |
| 24 | Ciprofloxacin | 0.008-0.015 | 0.008 | 0.015 | |
| 24 | Moxifloxacin | 0.008-0.06 | 0.015 | 0.03 | |
| 24 | Gemifloxacin | 0.002-0.015 | ≤0.004 | 0.008 | |
| Moraxella catarrhalis | 11 | JNJ-Q2 | ≤0.015 | ≤0.015 | ≤0.015 |
| 11 | Ciprofloxacin | ≤0.015-0.25 | 0.06 | 0.06 | |
| 11 | Moxifloxacin | 0.06 | 0.06 | 0.06 | |
| 11 | Gemifloxacin | ≤0.015-0.03 | ≤0.015 | ≤0.015 | |
| Escherichia coli, ciprofloxacin susceptible and intermediate | 30 | JNJ-Q2 | 0.015-0.5 | 0.06 | 0.25 |
| 30 | Ciprofloxacin | 0.008-2 | 0.015 | 0.25 | |
| 30 | Levofloxacin | 0.015-2 | 0.03 | 0.5 | |
| 30 | Moxifloxacin | 0.03-2 | 0.06 | 0.5 | |
| E. coli, ciprofloxacin resistant | 20 | JNJ-Q2 | 1-16 | 4 | 16 |
| 20 | Ciprofloxacin | 16->256 | 64 | 256 | |
| 16 | Levofloxacin | 4-128 | 16 | 64 | |
| 20 | Moxifloxacin | 8->256 | 32 | 128 | |
| 20 | Gemifloxacin | 16->128 | 32 | 64 | |
| Enterobacter cloacae | 26 | JNJ-Q2 | 0.03-0.25 | 0.12 | 0.12 |
| 26 | Ciprofloxacin | ≤0.004-0.25 | 0.015 | 0.06 | |
| 26 | Levofloxacin | 0.008-0.12 | 0.06 | 0.12 | |
| 26 | Moxifloxacin | 0.06-0.25 | 0.06 | 0.12 | |
| Enterobacter aerogenes | 26 | JNJ-Q2 | 0.06-1 | 0.12 | 0.25 |
| 26 | Ciprofloxacin | 0.008-0.25 | 0.03 | 0.03 | |
| 26 | Levofloxacin | 0.03-0.5 | 0.06 | 0.06 | |
| 26 | Moxifloxacin | 0.03-1 | 0.12 | 0.25 | |
| Klebsiella pneumoniae | 27 | JNJ-Q2 | ≤0.015-1 | 0.12 | 0.25 |
| 27 | Ciprofloxacin | ≤0.004-1 | 0.03 | 0.25 | |
| 27 | Levofloxacin | 0.015-1 | 0.06 | 0.12 | |
| 27 | Moxifloxacin | 0.015-1 | 0.12 | 0.25 | |
| Serratia marcescens | 13 | JNJ-Q2 | ≤0.015-1 | 0.5 | 1 |
| 13 | Ciprofloxacin | 0.06-0.5 | 0.12 | 0.25 | |
| 13 | Moxifloxacin | 0.06-1 | 0.5 | 1 | |
| 13 | Gemifloxacin | 0.015-1 | 0.25 | 0.5 | |
| Proteus mirabilis | 11 | JNJ-Q2 | 0.12-0.5 | 0.25 | 0.5 |
| 11 | Ciprofloxacin | 0.015-0.06 | 0.03 | 0.06 | |
| 11 | Moxifloxacin | 0.25-0.5 | 0.5 | 0.5 | |
| 11 | Gemifloxacin | 0.06-0.25 | 0.12 | 0.25 | |
| Providencia stuartii | 10 | JNJ-Q2 | 0.5-4 | 2 | 4 |
| 10 | Ciprofloxacin | 1-128 | 32 | 64 | |
| 10 | Levofloxacin | 4-64 | 16 | 64 | |
| 10 | Moxifloxacin | 8-64 | 32 | 64 | |
| Citrobacter freundii | 13 | JNJ-Q2 | 0.06-8 | 2 | 8 |
| 13 | Ciprofloxacin | 0.015->4 | 2 | >4 | |
| 13 | Moxifloxacin | 0.06->8 | 2 | >8 | |
| 13 | Gemifloxacin | 0.015->4 | 1 | >4 | |
| Pseudomonas aeruginosa | 28 | JNJ-Q2 | 0.5-4 | 1 | 2 |
| 28 | Ciprofloxacin | 0.12-1 | 0.25 | 0.5 | |
| 14 | Levofloxacin | 0.5-2 | 0.5 | 2 | |
| 28 | Moxifloxacin | 0.5-8 | 2 | 4 | |