TABLE 3.
Characterization of in vitro bactericidal activities of JNJ-Q2 and moxifloxacin against S. pneumoniae clinical isolates by time-kill methods
| Isolate | Agent | MIC (μg/ml) | Log10 decrease (Δlog10 CFU/ml) in viable cells recovered ata: |
|||
|---|---|---|---|---|---|---|
| 6 h |
24 h |
|||||
| 2× MIC | 4× MIC | 2× MIC | 4× MIC | |||
| OC 7189 | JNJ-Q2 | 0.015 | 4.0 | 4.2 | 7.5 | 7.2 |
| MXFb | 0.25 | 3.3 | 4.1 | 7.1 | 7.4 | |
| OC 6608 | JNJ-Q2 | 0.06 | 3.8 | 4.7 | 5.8 | 7.1 |
| MXF | 2 | 3.3 | 3.7 | 5.5 | 6.6 | |
| OC 5462 | JNJ-Q2 | 0.06 | 3.2 | 3.4 | 3.3 | 6.8 |
| MXF | 1 | 2.3 | 2.7 | 2.7 | 6.8 | |
| OC 7376 | JNJ-Q2 | 0.12 | 4.4 | 5.3 | 6.8 | 6.3 |
| MXF | 2 | 3.0 | 3.6 | 6.8 | 6.8 | |
| OC 6790 | JNJ-Q2 | 0.12 | 3.6 | 3.6 | 7.2 | 6.8 |
| MXF | 4 | 2.7 | 2.7 | 6.7 | 6.0 | |
| OC 7368 | JNJ-Q2 | 0.12 | 4.0 | 3.7 | 7.2 | 6.9 |
| MXF | 4 | 2.6 | 2.3 | 5.8 | 6.3 | |
| OC 7348 | JNJ-Q2 | 0.12 | 3.8 | 3.6 | 7.0 | 6.5 |
| MXF | 8 | 2.8 | 3.0 | 6.7 | 6.6 | |
| OC 6585 | JNJ-Q2 | 0.25 | 3.9 | 4.3 | 6.6 | 6.6 |
| MXF | 8 | 2.8 | 3.4 | 4.7 | 6.6 | |
| OC 6610 | JNJ-Q2 | 0.5 | 3.4 | 3.5 | 5.0 | 6.9 |
| MXF | 16 | 2.5 | 2.5 | 5.2 | 4.4 | |
a
Log10 decrease in the numbers of CFU/ml recovered at 6 or 24 h in comparison to the numbers recovered at 0 h.
b
MXF, moxifloxacin.