TABLE 1.

In vitro activity of posaconazole^a against 50 clinical strains of Rhizopus oryzae determined by broth microdilution, disk diffusion, and minimal fungicidal concentration studies

R. oryzae PSC susceptibility and isolate	MIC (μg/ml)	IZD (mm)	MFC (μg/ml)
Susceptible
UTHSC 03-228	0.25	25	1
UTHSC 06-3913	0.50	20	4
UTHSC 04-278	1	18	>16
UTHSC 06-4133	0.5	23	1
UTHSC 02-2882	0.25	22	0.5
UTHSC 04-443	0.5	22	1
UTHSC 04-1241	0.5	22	0.5
UTHSC 06-89	0.25	23	1
UTHSC 04-1613	0.5	22	0.5
UTHSC 04-2459	1	18	0.5
UTHSC 06-731	0.5	17	0.5
UTHSC 04-2159	0.5	20	1
UTHSC 2868	1	19	8
UTHSC 06-1080	1	18	>16
UTHSC 06-4152	0.25	22	1
UTHSC 06-329	0.5	20	0.5
UTHSC 05-2975	1	20	2
UTHSC 03-1826	0.5	18	0.5
UTHSC 05-1502	0.5	21	1
UTHSC 06-1351	0.25	25	0.5
UTHSC 06-4035	0.5	17	0.5
UTHSC 05-3132	0.5	20	0.5
UTHSC 03-547	0.25	25	0.5
UTHSC 05-197	0.25	21	0.5
UTHSC 02-439	0.25	22	0.5
UTHSC 06-2457	1	14	>16
UTHSC 03-511	0.25	22	1
UTHSC 03-3110	1	17	1
UTHSC 03-2970	1	20	4
UTHSC 05-1817	0.25	25	2
UTHSC 412-546	1	15	8
UTHSC 06-434	1	15	1
UTHSC 06-1301	0.5	25	1
UTHSC 05-3580	0.5	25	1
UTHSC 05-2447	1	17	1
UTHSC 04-1220	0.5	20	1
UTHSC 06-2374	0.5	23	1
UTHSC 03-112	0.5	20	1
UTHSC 06-4336	0.5	20	1
UTHSC 06-3827	1	18	16
UTHSC 03-299	1	15	>16
UTHSC 05-3111	0.25	20	2
UTHSC 05-1679	0.5	18	0.5
Intermediate
UTHSC 03-285	2	14	>16
UTHSC 07-365	2	15	16
UTHSC 03-285	2	15	>16
UTHSC 05-3032	2	14	>16
UTHSC 04-3109	2	14	>16
UTHSC 05-114	2	15	16
UTHSC 03-3165	2	16	16

^aPosaconazole was administered 24 h after challenge of the mice with the fungal strains.