TABLE 2.
Time needed to achieve 50, 90, 99, and 99.9% growth reduction from that of the starting inoculuma
| Agent | Growth parameter | Mean time (h) at the indicated concn (mg/liter) |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
C. orthopsilosis |
C. metapsilosis |
C. parapsilosisb |
||||||||||||||
| 0.25 | 1 | 4 | 16 | 32 | 0.25 | 1 | 4 | 16 | 32 | 0.25 | 1 | 4 | 16 | 32 | ||
| CAS | T50 | 17.50 | 7.45 | 3.42 | 3.86 | 10.53 | >48 | 22.30 | 7.70 | 2.59 | 1.99 | >48 | 22.30 | 7.70 | 2.59 | 1.99 |
| T90 | >48 | 24.75 | 11.35 | 12.82 | 34.97 | >48 | >48 | 25.58 | 8.61 | 6.60 | >48 | >48 | 25.58 | 8.61 | 6.60 | |
| T99 | >48 | >48 | 22.70 | 25.64 | >48 | >48 | >48 | >48 | 17.21 | 13.20 | >48 | >48 | >48 | >48 | >48 | |
| T99.9 | >48 | >48 | 34.05 | 38.46 | >48 | >48 | >48 | >48 | 25.82 | 19.80 | >48 | >48 | >48 | >48 | >48 | |
| MCF | T50 | 15.93 | 3.05 | 1.66 | 1.38 | 1.54 | >48 | 3.06 | 1.77 | 1.45 | 1.43 | NK | NK | 17.60 | 9.50 | 6.16 |
| T90 | >48 | 10.13 | 5.53 | 4.59 | 5.11 | >48 | 10.15 | 5.89 | 4.80 | 4.76 | NK | NK | >48 | 31.55 | 20.45 | |
| T99 | >48 | 20.26 | 11.06 | 9.17 | 10.22 | >48 | 20.30 | 11.79 | 9.61 | 9.53 | NK | NK | >48 | >48 | >48 | |
| T99.9 | >48 | 30.40 | 16.59 | 13.76 | 15.34 | >48 | 30.46 | 17.68 | 14.41 | 14.29 | NK | NK | >48 | >48 | >48 | |
| AND | T50 | 17.40 | 6.36 | 2.73 | 1.88 | 1.48 | 7.74 | 1.57 | 2.39 | 1.51 | 1.41 | NK | NK | 26.41 | 7.84 | 4.20 |
| T90 | >48 | 21.14 | 9.08 | 6.24 | 4.91 | 25.71 | 5.22 | 7.94 | 5.01 | 4.69 | NK | NK | >48 | 26.04 | 13.95 | |
| T99 | >48 | 42.28 | 18.17 | 12.48 | 9.81 | 51.41 | 10.44 | 15.89 | 10.02 | 9.37 | NK | NK | >48 | >48 | 27.89 | |
| T99.9 | >48 | >48 | 27.25 | 18.73 | 14.72 | 77.12 | 15.67 | 23.83 | 15.03 | 14.06 | NK | NK | >48 | >48 | 41.84 | |
a
CAS, caspofungin; MCF, micafungin; AND, anidulafungin; NK, no killing; T50, time needed to achieve 50% growth reduction from that of the starting inoculum; T90, time needed to achieve 90% growth reduction from that of the starting inoculum; T99, time needed to achieve 99% growth reduction from that of the starting inoculum; T99.9, time needed to achieve 99.9% growth reduction from that of the starting inoculum.
b
Corresponding concentrations of AND for C. parapsilosis are 0.03, 0.12, 0.5, 2, and 8 mg/liter.