TABLE 3.

Summary of selective inhibitors of type III secretion

^aPercent inhibition of exoT-lux RLU/percent inhibition of lac-lux RLU, both at 50 μM compound.

^bPercent inhibition of exoT-lux RLU in the absence of serum/percent inhibition of exoT-lux RLU in the presence of 10% fetal calf serum, both at 50 μM compound.

^cCompound concentration at which secretion of ExoS-βLA fusion protein from P. aeruginosa strain MDM973 is reduced by 50%. All IC₅₀ and CC₅₀ values are presented in μM.

^dCompound concentration at which the viability of HeLa cells cultured in serum-free medium is reduced by 50%.

^eSelectivity of T3SS inhibition as measured by the ratio of potency of the compound in the HeLa cell viability assay vs the T3SS inhibition assay.

^fCompound concentration at which secretion of YopE-βLA fusion protein from Y. pestis strain JG153/pMM85 is reduced by 50%.