TABLE 1.
Therapeutic efficacies against M. tuberculosis H37Rv replicating in the lungs of B6 micea
| Compound | Vehicle | ED99 (mg/kg)b | EDmax (mg/kg)c |
|---|---|---|---|
| Isoniazid | Water | 0.95 (0.86-1.07) | 25 |
| Rifampin | Water-20% Encapsine | 9.8 (9.0-10.7) | 30 |
| Pyrazinamide | Water-1% methylcellulose | 362.0 (319.0-409.0) | ≥1,000d |
| Ethambutol | Water-1% methylcellulose | 21.6 (19.9-23.5) | 300 |
| Moxifloxacin | Water-20% Captisol | 27.7 (26.2-29.3) | 100 |
| Linezolid | Water-1% methylcellulose | 28.0 (23.7-32.9) | ≥300d |
a
Data are from five mice/group.
b
The dose that results in a 2-log reduction in bacterial burden in the lungs of mice. Data were calculated from individual log10 CFU/lung values fit to a logistic equation. Data are expressed as the ED99, with the 95% confidence interval of the ED99 shown in parentheses.
c
Estimated empirically as the lowest dose administered to mice that reduced bacterial burden in the lungs to a level statistically indistinguishable from reductions achieved with higher doses.
d
Highest dose used in the assay.