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Cutaneous model of IA. (A) A circumscribed skin lesion with peripheral enhancement appeared 48 h after subcutaneous injection of 5 × 106 A. fumigatus conidia in cyclophosphamide-treated nude BALB/c mice. (B, C) Histopathologic examination of thigh tissue sections revealed hyphal proliferation in the dermis and invasion of muscle tissue (hematoxylin and eosin, ×200 magnification [B]; GMS, ×200 magnification [C]).
