TABLE 1.
Mendelian ratios in live-born PARP1/H2AX and PARP1/53BP1 mice
| Intercross (no. of litters) | Resulting phenotype |
No. observed (%) | No. expected (%) | Ratio | |
|---|---|---|---|---|---|
| PARP1 | H2AX or 53BP1 | ||||
| PARP1+/−/H2AX+/−(14) | +/+ | +/+ | 5 (6.8) | 6.3 (6.25) | 1/16 |
| +/+ | +/− | 9 (12.2) | 12.6 (12.5) | 1/8 | |
| +/+ | −/− | 1 (1.4) | 6.3 (6.2) | 1/16 | |
| +/− | +/+ | 23 (28.4) | 12.6 (12.5) | 1/8 | |
| +/− | +/− | 32 (41.9) | 25.3 (25) | 1/4 | |
| +/− | −/− | 11 (13.5) | 12.6 (12.5) | 1/8 | |
| −/− | +/+ | 4 (5.4) | 6.3 (6.25) | 1/16 | |
| −/− | +/− | 16 (18.9) | 12.6 (12.5) | 1/8 | |
| −/− | −/− | 0 (0) | 6.3 (6.25) | 1/16 | |
| Total | 101 | ||||
| PARP1−/−/H2AX+/− × PARP1+/−/H2AX+/− (4) | +/− | +/+ | 2 (11.1) | 2.25 (12.5) | 1/8 |
| +/− | +/− | 7 (38.9) | 4.5 (25) | 1/4 | |
| +/− | −/− | 4 (22.2) | 2.22 (12.5) | 1/8 | |
| −/− | +/+ | 1 (5.6) | 2.25 (12.5) | 1/8 | |
| −/− | +/− | 4 (22.2) | 4.5 (25) | 1/4 | |
| −/− | −/− | 0 (0) | 2.25 (12.5) | 1/8 | |
| Total | 18 | ||||
| PARP1−/−/H2AX+/− × PARP1−/−/H2AX+/− (2) | −/− | +/+ | 3 (50.0) | 1.5 (25) | 1/4 |
| −/− | +/− | 3 (50.0) | 3 (50) | 1/2 | |
| −/− | −/− | 0 (0) | 1.5 (25) | 1/4 | |
| Total | 6 | ||||
| PARP1+/−/53BP1+/− (12) | +/+ | +/+ | 7.0 (8.4) | 5.2 (6.25) | 1/16 |
| +/+ | +/− | 8.0 (9.6) | 10.3 (12.5) | 1/8 | |
| +/+ | −/− | 9.0 (10.8) | 5.2 (6.25) | 1/16 | |
| +/− | +/+ | 9.0 (10.8) | 10.3 (12.5) | 1/8 | |
| +/− | +/− | 22.0 (26.5) | 20.7 (25) | 1/4 | |
| +/− | −/− | 10.0 (12.0) | 10.3 (12.5) | 1/8 | |
| −/− | +/+ | 5.0 (6.0) | 5.2 (6.25) | 1/16 | |
| −/− | +/− | 9.0 (10.8) | 10.3 (12.5) | 1/8 | |
| −/− | −/− | 4.0 (4.8) | 5.2 (6.25) | 1/16 | |
| Total | 83 | ||||