TABLE 3.
Frequency of spontaneous or drug-induced SCEs in cells deficient for PARP1 and 53BP1
| Phenotype | Treatment | No. of chromosomes | No. of SCEs | No. of SCEs/ chromosome | Pa |
|---|---|---|---|---|---|
| Wild type | 2,331 | 892 | 0.38 | ||
| PARP1−/− | 2,373 | 2,343 | 0.99 | 0.009 | |
| 53BP1−/− | 1,473 | 593 | 0.40 | 0.62 | |
| PARP1−/−/53BP1−/− | 1,490 | 1,456 | 0.98 | 0.031 | |
| Wild type | MMC | 1,900 | 1,300 | 0.70 | |
| PARP1−/− | MMC | 1,915 | 2,532 | 1.32 | 0.002 |
| 53BP1−/− | MMC | 1,229 | 947 | 0.77 | 0.14 |
| PARP1−/−/53BP1−/− | MMC | 1,521 | 2,022 | 1.33 | 0.03 |
| Wild type | HU | 1,322 | 1,563 | 1.18 | |
| PARP1−/− | HU | 1,401 | 2,603 | 1.86 | 0.07 |
| 53BP1−/− | HU | 1,213 | 1,338 | 1.1 | 0.92 |
| PARP1−/−/53BP1−/− | HU | 997 | 1,942 | 1.95 | 0.05 |
a
Relative to wild type.