TABLE 2.
Mouse infectivity and tissue viral titers of H1N1 and H5N1 viruses
| Virus | % wt loss (day p.i.)a | MID50b | LD50b | Viral titerc |
|||
|---|---|---|---|---|---|---|---|
| Day 3 p.i. |
Day 6 p.i. |
||||||
| Lung | Nose | Lung | Nose | ||||
| CA/4 | 5.3 (8) | 101.5 | >106 | 5.9 ± 0.9 | 1.5 ± 0.2 | 6.2 ± 0.1 | NDd |
| TX/15 | 1.5 (1) | 100.5 | >106 | 5.4 ± 1.0 | ND | 4.7 ± 0.8 | ND |
| Mex/4108 | 3.5 (3) | 101.5 | >106 | 6.9 ± 0.3 | 1.6 ± 0.5 | 5.6 ± 0.3 | 1.3 ± 0.3 |
| Mex/4482 | 19.0 (7) | 100.25 | >106 | 6.4 ± 0.2 | 1.2 ± 0.3 | 6.3 ± 0.4 | ND |
| Mex/4487 | 9.7 (8) | 102.75 | >106 | 6.9 ± 0.4 | 1.7 ± 0.1 | 5.9 ± 0.2 | 2.6 ± 1.0 |
| NJ/8 | 2.7 (1) | 102.75 | >106 | 6.0 ± 0.2 | ND | 5.9 ± 0.9 | ND |
| OH/2 | 14.5 (7) | 101.75 | 105.8 | 7.0 ± 0.3 | 1.4 ± 0.5 | 4.5 ± 0.1 | ND |
| 1918 | 22.4 (6) | 100.75 | 103.5 | 6.7 ± 0.1 | 1.5 ± 0.4 | 6.2 ± 0.1 | ND |
| VN/1203 | 23.4 (5) | 101.5 | 101.3 | 7.3 ± 0.1 | 2.0 ± 0.5 | 6.1 ± 0.4 | 3.5 ± 1.5 |
a
Mean maximum percent weight loss (5 mice per group) following inoculation with 105 PFU or EID50.
b
Fifty percent mouse infectious dose (MID50) and 50% lethal dose (LD50) are expressed as the PFU or EID50 required to give 1 MID50 or 1 LD50, respectively.
c
Virus endpoint titers are expressed as the mean log10 PFU/ml plus standard deviation of 3 to 6 mice per tissue.
d
ND, not detected. The limit of virus detection was 10 PFU/ml.