TABLE 4.
Impact of viral infection on the mouse lymphohemopoietic systemd
| Virus | Day 3 p.i. |
Day 6 p.i. |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WBCa | % LYb | % NEb | % MOb | Leukocytes/thymusc | WBCa | % LYb | % NEb | % MOb | Leukocytes/thymusc | |
| None (naïve mice) | 2.0 | 76.2 | 16.7 | 6.2 | 7.7 ± 0.1 | 2.0 | 76.2 | 16.7 | 6.2 | 7.7 ± 0.1 |
| CA/4 | 1.3 | 65.4* | 27.9* | 6.4 | 7.8 ± 0.2 | 1.5 | 68.2** | 23.9* | 7.4 | 7.7 ± 0.2 |
| TX/15 | 2.2 | 68.3* | 24.3 | 7.0 | 7.7 ± 0.1 | 1.0** | 68.9* | 21.0 | 8.9* | 7.6 ± 0.2 |
| Mex/4108 | 0.8** | 62.2** | 28.7** | 8.8 | 7.7 ± 0.1 | 0.8** | 65.3** | 25.2** | 8.5* | 7.5 ± 0.2 |
| Mex/4482 | 1.0** | 67.9** | 24.8** | 6.4 | 7.3 ± 0.1** | 1.5 | 73.2 | 19.5 | 6.6 | 7.3 ± 0.1** |
| Mex/4487 | 1.8 | 64.4** | 29.4** | 5.2 | 7.2 ± 0.1** | 1.7 | 55.5** | 34.9** | 6.9 | 7.0 ± 0.1** |
| NJ/8 | 1.2** | 74.5 | 17.3 | 6.9 | 7.7 ± 0.1 | 1.3* | 68.3* | 21.1 | 7.0 | 7.6 ± 0.1 |
| OH/2 | 1.0** | 59.7** | 29.4** | 7.8 | 7.5 ± 0.2 | 1.8 | 55.8** | 34.7** | 7.7 | 7.3 ± 0.2** |
| 1918 | 1.2* | 66.3* | 23.1** | 8.9 | 7.1 ± 0.1** | 1.6 | 52.9** | 38.1** | 6.7 | 6.8 ± 0.2** |
| VN/1203 | 1.3* | 50.3** | 36.3** | 9.9* | 7.0 ± 0.1** | 1.4* | 48.2** | 41.0** | 6.8 | 7.1 ± 0.1** |
a
Number of white blood cells (WBC) in whole blood, expressed as thousands of WBCs per microliter of whole blood.
b
Mean percentage of leukocytes that are lymphocytes (LY), neutrophils (NE), or monocytes (MO) from 3 to 7 mice per group.
c
Numbers of leukocytes are expressed as the mean log10 ± standard deviation of 3 to 6 thymi.
d
Statistical significance: *, P < 0.05, and **, P < 0.005, compared with naïve controls.