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. 2010 Feb 24;84(9):4579–4586. doi: 10.1128/JVI.02591-09

FIG. 1.

FIG. 1.

Vaginal infection with HSV and treatment with nucleotide PAMPs induce expression of type I and III IFN. C57BL/6 mice were infected intravaginally with 6.7 × 104 PFU of HSV-2 (A) or treated with 25 μg of ODN1826, 100 μg of poly(I:C):LyoVec, or 100 μg of poly(dA:dT):LyoVec (B to D). At the indicated time points posttreatment, vaginal wash samples were collected and levels of IFN-α/β bioactivity (top row) and total IFN-λ levels (bottom row) were measured. The data are shown as means ± SD (n = 4 to 7). T, time point.