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Effect of 4c on the conformational change of HA, as demonstrated by trypsin digestion. A/X-31 virus was incubated at 37°C for 15 min in the presence of various concentrations of 4c, and the pH was lowered to 5.0. After neutralization, the mixtures were treated with trypsin. The lysates were subjected to Western blot analysis under reducing conditions and using an anti-HA1 antibody. The low-pH-induced conformational change of the HA resulted in the disappearance of the HA1 band.
