TABLE 5.
Bioassay results from naïve deer cohorts inoculated with CWD+ blood components
| Deer cohort no. | Inoculum | Tonsil PrPCWD result (no. positive/total) at postinoculation time of: |
Terminal necropsy PrPCWD resulta (no. positive/total) at 19 mo p.i. | % CWD+ | ||
|---|---|---|---|---|---|---|
| 3 mo | 6 mo | 12 mo | ||||
| 1 | Whole blood | 0/8 | 4/8 | 8/8 | 8/8 | 100 |
| 2 | Blood mononuclear cells | 0/4 | 1/4 | 2/4 | 4/4 | 100 |
| 3 | Cell-free plasma | 0/4 | 0/4 | 0/4 | 0/4 | 0 |
| 4 | 2-104+ B cells | 0/4 | 1/4 | 2/4 | 4/4 | 100 |
| 5 | CD41/61+ platelets | 0/4 | 0/4 | 1/4 | 3/4 | 75 |
| 6 | CD14+ monocytes | 0/4 | 0/4 | 0/4 | 0/4 | 0 |
| 7 | CWD− whole blood | 0/2 | 0/2 | 0/2 | 0/2 | 0 |
a
Retropharyngeal lymph node, tonsil, and medulla oblongata at obex.