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Speculative model for Chk2 regulation of OriP. Chk2 is shown to associate with phosphorylated TRF2 in the G1/S phase. Phosphorylated TRF2 is compromised in RNA binding and ORC recruitment, which may prevent replication initiation and provide a Chk2-dependent checkpoint delay in replication initiation. In the mid-S phase, Chk2 dissociates from TRF2 and returns OriP to a competent replication origin.
