TABLE 5.
Comparison of the polyprotein sequence of ED43 derived from chimpanzee plasma pool with the polyproteins of other genotype 4a isolates at the amino acid level
| Genomic region | Amino acid positionb | Comparison of the consensus sequence of ED43 polyprotein with the published sequences of indicated isolatesa: |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Y11604 (ED43) |
DQ418782 (01-09) |
DQ418783 (02-42) |
DQ418784 (02C) |
DQ418787 (F753) |
DQ418788 (F7157) |
DQ418789 (L835) |
DQ516084 (25) |
||||||||||
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||
| Core | 1-191 | 2 | 1.0 | 2 | 1.0 | 3 | 1.6 | 3 | 1.6 | 2 | 1.0 | 2 | 1.0 | 2 | 1.0 | 3 | 1.6 |
| E1 | 192-383 | 1 | 0.5 | 11 | 5.7 | 8 | 4.2 | 10 | 5.2 | 11 | 5.7 | 11 | 5.7 | 14 | 7.3 | 9 | 4.7 |
| E2 | 384-746 | 1 | 0.3 | 57 | 15.7 | 41 | 11.3 | 46 | 12.7 | 48 | 13.2 | 54 | 14.9 | 53 | 14.6 | 46 | 12.7 |
| HVR1 | 384-410 | 0 | 0 | 16 | 59.3 | 10 | 37.0 | 10 | 37.0 | 16 | 59.3 | 16 | 59.3 | 15 | 55.6 | 11 | 40.7 |
| p7 | 747-809 | 1 | 1.6 | 13 | 20.6 | 10 | 15.9 | 10 | 15.9 | 9 | 14.3 | 9 | 14.3 | 10 | 15.9 | 9 | 14.3 |
| NS2 | 810-1026 | 7 | 3.2 | 30 | 13.8 | 28 | 12.9 | 30 | 13.8 | 30 | 13.8 | 30 | 13.8 | 27 | 12.4 | 29 | 13.4 |
| NS3 | 1027-1657 | 11 | 1.7 | 21 | 3.3 | 23 | 3.6 | 31 | 4.9 | 26 | 4.1 | 22 | 3.5 | 24 | 3.8 | 23 | 3.6 |
| NS4A | 1658-1711 | 0 | 0 | 1 | 1.9 | 1 | 1.9 | 1 | 1.9 | 2 | 3.7 | 0 | 0 | 1 | 1.9 | 1 | 1.9 |
| NS4B | 1712-1972 | 11 | 4.2 | 2 | 0.8 | 3 | 1.1 | 3 | 1.1 | 4 | 1.5 | 4 | 1.5 | 5 | 1.9 | 10 | 3.8 |
| NS5A | 1973-2417 | 20 | 4.5 | 27 | 6.1 | 22 | 4.9 | 37 | 8.3 | 21 | 4.7 | 24 | 5.4 | 22 | 4.9 | 29 | 6.5 |
| NS5B | 2418-3008 | 13 | 2.2 | 25 | 4.2 | 26 | 4.4 | 30 | 5.1 | 24 | 4.1 | 23 | 3.9 | 22 | 3.7 | 43 | 7.3 |
| ORF | 1-3008 | 67 | 2.2 | 189 | 6.3 | 165 | 5.5 | 201 | 6.7 | 177 | 5.9 | 179 | 6.0 | 180 | 6.0 | 202 | 6.7 |
a
See Table 4, footnote a.
b
The amino acid positions refer to pED43.