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Replication of wild-type SI06 variants in the respiratory tract of ferrets
| Virus | Amino acids at HA residues 190 and 226 | Virus titer (log10 EID50 ± SE) in: |
|
|---|---|---|---|
| NT | Lung | ||
| bWT SI06 | Heterologousa | 5.8 ± 0.4 | 5.8 ± 0.2 |
| DR | 4.4 ± 0.8 | <1.5 | |
| NQ | 5.6 ± 0.4 | 5.4 ± 0.4 | |
| AQ | 5.5 ± 0.1 | 5.1 ± 0.2 | |
| rWT SI06 | DR | 5.8 ± 0.2 | <1.5 |
| AR | 6.1 ± 0.9 | <1.5 | |
| DQ | 7.2 ± 0.2 | 6.3 ± 0.5 | |
| AQ | 6.9 ± 0.2 | 6.3 ± 0.3 | |
The original virus contained sequence variations in the HA protein.
