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vICA/pUL36 prevents extrinsic apoptosis of infected HFs. (A to O) Examples of Hoechst fluorescence from infected cultures exposed to anti-Fas (α-Fas) or TNF and cycloheximide (MOI of 3). (P) Resistance to Fas-mediated apoptosis of RC2792-infected HFs mediated by transfection of a plasmid encoding UL36, UL36mut, or a control (empty vector) along with DsRED. Graphed are numbers of surviving transfected/infected cells (indicated by DsRED) along with standard deviations.
