FIG. 8.

vICA/pUL36 inhibits HCMV-induced death of monocytes infected at early times of macrophage differentiation. (A) Representation of UL36-encoding plasmids used to complement growth of UL36-deficient virus in THP-1 cells. The asterisk indicates the relative location of introduced mutations. (B and C) Numbers of GFP⁺ cells on day 4 postinfection with RC2792 or RQ2792 of THP-1 cells transfected with UL36-encoding or control plasmids prior to treatment with TPA and HC for 24 h. Data are means ± standard deviations.