FIG. 1.
Effect of CN mutations from patients' RTs on NNRTI resistance. Fold changes in the resistance level to NVP, DLV, EFV, and ETR are shown as vertical bars (mean of two or more independent experiments ± standard error) for viruses containing wild-type pol and CN from treatment-experienced patients' RT T-3, T-4, T-6, T-8, and T-10 (A) or CN from treatment-naïve patients' RT N-16, N-18, N-19, N-22, and N-24 (B). An asterisk within the bar indicates a statistically significant increase in resistance versus wild-type (WT) control (t test, P < 0.05).