TABLE 1.

Detection of oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus in Israeli patients by qRT-PCR and by sequence analysis

Patient no.	Sample type	Date sample collected (day-mo-yr)	qRT-PCR assay (Ct)a				N*823 sequencing resultb
			Influenza A pandemic (H1N1) 2009	H275 (sensitive)	H275Y (resistant)	Interpretation
1	Throat/nose	30-07-09	17	24	Neg	WT	C
	Throat/nose	09-08-09	20	29	27	WT and mutant	T/C
2	Throat/nose	14-08-2009	26.4	Neg	29.7	Mutant	T
	Throat/nose	16-08-2009	19.4	Neg	25.3	Mutant	T
	Throat/nose	19-08-2009	Neg	Neg	Neg		ND
3	Throat/nose	16-08-2009	21.5	Neg	25	Mutant	T
4	Throat/nose	20-09-2009	16	19	Neg	WT	C
	Throat/nose	03-10-2009	29	34.1	33.6	WT and mutant	T/C
	Throat/nose	05-10-2009	30	Neg	35.7	Mutant	T
5	Throat/nose	11-10-2009	25.6	Neg	28.3	Mutant	T
	Throat/nose	15-10-2009	25.6	Neg	29	Mutant	T
	Throat/nose	20-10-2009	26.2	Neg	28.5	Mutant	T
6	Throat/nose	19-11-2009	17.5	24.5	21.8	WT and mutant	T
	Endotracheal	19-11-2009	22.2	25.3	Neg	WT	C
	Throat/nose	23-11-2009	16.1	33.3	21	WT and mutant	T
	Endotracheal	23-11-2006	27.1	32.8	31	WT and mutant	T/C

^aNeg, negative result; ND, not determined; WT, wild type.

^bThe nucleotide(s) found at position 823 (N*823) in the neuraminidase 1 gene.