FIG. 4.

The dynamics of NVP-resistant-HIV-1 selection and decay are compared in the HIV-1 RNA and DNA of subjects known to harbor mutations at each codon. The prevalence of samples with detectable resistance (A to C) and the concentrations (D to F) of NVP-resistant variants as determined by oligonucleotide ligation assay (OLA) at each point in time are shown by codon. For all codons, the prevalence of resistance and the estimated concentrations of resistant viruses peak sooner in RNA but decay more slowly in DNA.