TABLE 5.

Univariate and multivariate analyses of risk factors for 14-day and 30-day mortality among patients with bloodstream infections due to extended-spectrum β-lactamase-producing Escherichia coli

Time of mortality measure and risk factor	No. of patients who died/total no. of patients (%)	RR (95% CI)	P for RR	Adjusted OR (95% CI)	P for adjusted OR
14-day mortality
Gender
Male	13/54 (24)	1.0 (0.5-2.1)	0.8
Female	11/42 (26)
Age (yr)
>65	12/45 (27)	1.1 (0.5-2.2)	0.7
14-65	12/51 (24)
Charlson index
>2	15/40 (38)	2.3 (1.1-4.7)	0.01
0-2	9/56 (16)
Pitt score
>1	17/37 (46)	3.8 (1.7-8.4)	<0.001	3.9 (1.2-12.9)	0.02
0-1	7/59 (12)
High-risk sourcea
Yes	19/48 (40)	3.8 (1.5-9.3)	0.001	5.5 (1.4-21.9)	0.01
No	5/48 (10)
Severe sepsis or shock
Yes	15/27 (56)	4.2 (2.1-8.5)	<0.001	4.6 (1.4-15.2)	0.01
No	9/69 (13)
Resistance score
>3	8/16 (50)	2.5 (1.2-4.8)	0.02	6.5 (1.4-30.0)	0.01
0-3	16/80 (20)
Empirical treatment
Inappropriate	11/43 (26)	1.0 (0.5-2.0)	0.9
Appropriate	11/53 (25)
30-day mortality
Gender
Male	16/54 (30)	1.0 (0.05-1.9)	0.8
Female	13/42 (26)
Age (yr)
>65	14/45 (31)	1.0 (0.5-1.9)	0.8
14-65	15/51 (29)
Charlson index
>2	18/40 (45)	2.3 (1.2-4.3)	0.008	2.7 (0.8-9.0)	0.09
0-2	11/56 (20)
Pitt score
>1	21/37 (57)	4.3 (2.0-9.0)	<0.001	5.5 (1.9-21.3)	0.002
0-1	8/59 (14)
High-risk sourcea
Yes	23/48 (48)	3.8 (1.7-9.0)	<0.001	5.8 (1.5-21.7)	0.008
No	6/48 (13)
Severe sepsis or shock
Yes	17/27 (63)	3.7 (2.0-6.6)	<0.001	3.5 (1.1-11.6)	0.03
No	12/69 (17)
Resistance score
>3	8/16 (50)	1.9 (1.0-3.5)	0.07	4.9 (1.0-23.0)	0.04
0-3	21/80 (26)
Empirical treatment
Inappropriate	13/43 (30)	1.0 (0.5-1.8)	0.9
Appropriate	16/53 (30)

^aHigh-risk source: intra-abdominal infection, respiratory tract infection, and unknown source.