TABLE 3.
GenoType MTBDRsl test results for the detection of ethambutol resistance in 52 M. tuberculosis strainsa
| No. of strains | Ethambutol resistance phenotypeb | No. of strains with the following result for the embB gene by sequencing: |
No. of strains with the following result by the MTBDRsl test: |
|||
|---|---|---|---|---|---|---|
| wt | M306V | M306I | wt | Mutationc | ||
| 28 | R | 14 | 14 (ΔWT, MUTM306V) | |||
| 1 | 1 (ΔWT, MUTM306I)d | |||||
| 1 | 1 (ΔWT)e | |||||
| 12 | 12 | |||||
| 24 | S | 22 | 22 | |||
| 1 | 1 (ΔWT, MUTM306V) | |||||
| 1 | 1 (ΔWT)f | |||||
a
wt, wild-type.
b
R, resistant; S, susceptible.
c
ΔWT, lack of hybridization with the the wild-type probe.
d
M306I, base exchange (ATG→ATA) at codon 306.
e
M306I, base exchange (ATG→ATC [not detected directly]) at codon 306.
f
M306I, base exchange (ATG→ATT [not detected directly]) at codon 306.