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Comparison of binding affinity on para, meta, ortho compounds.
| Series | Ki (nM) para | Ki (nM) Meta | Ki (nM) ortho | ortho/para |
|---|---|---|---|---|
| 1 | 3,900 | >100,000 | >100,000 | >25 |
| 2 | 45,000 | ND1 | ND | ND |
| 3 | 76 | 418 | 94,900 | 1,249 |
| 4 | 163 | 517 | 1,200 | 7 |
| 5 | 667 | 982 | 14,490 | 22 |
| 6 | 313 | ND | >100,000 | 319 |
| 7 | 67 | 7,432 | NS2 | 1113 |
| 8 | 1,027 | 15,670 | NS | 153 |
| 9 | 240 | 2,264 | 1,514 | 6 |
ND, not determined see results.
NS, not synthesized.
meta/para since ortho value is not available.
